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There are two approaches to the question of whether vitamin C has an impact on cancer.First, within the normal range of dietary intake without additional dietary supplementation, are people who consume more vitamin C at lower risk for developing cancer, and if so, does an orally consumed supplement have the same benefit?Doing so converts vitamin C to an oxidized state - either as semidehydroascorbic acid or dehydroascorbic acid.These compounds can be restored to a reduced state by glutathione and NADPH-dependent enzymatic mechanisms.


The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747, and from 1796 lemon juice was issued to all Royal Navy crewmen.A 2012 Cochrane review reported no effect of vitamin C supplementation on overall mortality.


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